Taking a break…

Hi everybody,

My current day job is becoming more and more oriented towards the public markets, which has the potential to create conflicts and significantly limits my ability to discuss publicly traded companies. Given this situation I decided to take a break from publishing on this site. As you may guess, this wasn’t an easy decision… this blog and its readers have been a significant part of my life for over a decade but it is the inevitable one given the circumstances. I am very grateful and feel fortunate to have had the opportunity to interact with all of you. I am going to miss it.

Take care,


79 thoughts on “Taking a break…

  1. My list would exclude cos. that will need to replenish their cash in the next year. So companies that are either cash flow positive or have 2 years worth of cash. I like ACAD and VKTX. ACAD has an approved drug that is generating significant sales and there are additional blockbuster indications teed up for FDA approval. VKTX has $270M in cash as of 12/19 and a market cap as of today of $300M. As for timing? I’m going to give it another week. GLTA


  2. Too bad Ohad!
    Your valuable analysis of the biotech field is going to missed us.
    Hopefully we’ll continue to actively work with you and Pontifax.
    All the best


  3. Hi Les,

    I like some with tiny EV (less than about $100m) but product near market, like e.g. FENC, ALBO, MIRM, ALBO

    I like as you mentioned VKTX at basically 0 EV. Also PIRS (more risky) at 0 EV. XENE also not much EV.

    I like companies with high cash and interesting programs like ZYME, MOR, ARNA (all ~ half cash)

    I also like e.g. AMRN, AUPH, AXSM, MDGL,..

    There are steals out there – but nobody knows when the panic of the mass raches its maximum. So I am selectively buying small portions to add to my quite big long-term investments, especially on days when everything goes down a lot (and not on a rebound-day like today)

    Wish you all good decisions



  4. Hey Everyone,

    I have bought some XAIR and added to my position in CAPR as they are expanding their exosome platform for use in vaccine – going after c-19 – and bought on an exsomome KOL from Johns Hopkins to the fold – in last Earning call CEO stated they are going to make announcements regarding exosomes as vaccine platform and they are seeking grant funding. Market cap is $4M!



  5. One way to avoid conflict is to talk about technologies you like in general. You’ve been incredible asset, I hope you come back. But you have a well-deserved break my friend 🙂


  6. Hi everyone, I think someone asked the question for other interesting blogs. I joined Integrated BioSci Investing on Seeking Alpha already some time ago. Good content, great community, and very interactive. Give it a try if you are interested.

    Thanks Ohad for everything, I miss you and hope you will come back at one point! I will keep this page open on my computer just in case …


  7. Ohad Readers,
    Can anyone, or collectively as a group, recommend a list of biotechs that meet the following criteria:
    • Good Cash position allowing operations through 2021
    • Phase 2 or 3 studies that are currently enrolled that are unlikely to be interrupted by the Covid-19 situation.
    • Current market value reduction improving future return potential.



  8. Frank

    That would be two of Ohads favorites XENE and ZYME. Take the time to read his previous posts.

    As for delays, neither company has made a public announcement as of yet re: trials, but you can expect most trials have hit some sort of delay


  9. Hey all!
    I really appreciate the twitter handles-I have followed Dan I believe. It’s mostly my work account, so I don’t tweet stock picks, but appreciate everyone tweeting.

    Does anyone follow hedge funds? I had a pretty good run following Seth Klarman’s bio picks, but I’d say over the past year or so that’s been less of a focus for his fund. I am thinking of following Perceptive, though their portfolio is enormous. I’m a big fan of buying small caps institutional capital is acquiring, particularly if there is more than one fund on board.

    Anyway I sold about a third of my overall portfolio and am using this as an opportunity to go long on several biotech names. No high-conviction buys, but spreading bets around and will continue to do so.


  10. Alex, AKRO good data for p2a at week 12. Stat sig liver fat reductions across all doses. Absolute: 12-14%, relative 72%. By comparison MDGL had ~40% relative reductions at week 12


  11. re: strong cash positions, I noticed this page-http://www.biotechduediligence.com/valuation.html

    The following trade close to EV, probably a good jumping off point for further study:


  12. OH-Thanks for correcting/updating the back-end of the site. I enjoy being able to research names and this is such a great resource.


  13. Ponitifax bought 2M GNCA shares at the resent offering plus an option to buy additional 2M shares at 2.25.
    GNCA was in the Ohad’s portfolio in the past, so there must be something there,
    009 data this Thu, Jul 30. Chance for good data 50-50. 011 is a better drug, but a year away from data.

    If someone follows my top pick BTAI, would be sitting on 1000% return in 9 mo.


  14. Alex
    I can’t post the link but here is the list of Pontifax Closing Schedule:
    Pontifax (Cayman): 305,039 shares + 305,039 warrants
    Pontifax (Israel): 1,142,018 shares + 1,142,018 warrants
    Pontifax (China): 443,698 shares + 443,698 warrants
    Pontifax (LS Fund): 210,084 shares + 210,084 warrants

    Check also TORC. Reverse merger in Sep. with Adicet Bio- see Pontifax portfolio.
    Ohad was talking that the future is allogenic CAR-T but that the the most interesting technologies are still private. Well Adicet Bio is probably one of those innovative companies, still private, he was talking about. They have allogenic gamma-delta CAR-T platform. So if you buy TORC you get pre-IPO price for Adicet at about $10 /share (TORC is 25% of the total) plus CVR of the current TORC programs, which might be worth something.


  15. Andre , Alex and of course, Ohad,
    Any update on the recent market reaction to ZYME, RGNX, XENE, GNCA?
    Re: VKTX, how much of it’s EV is tied up in NASH (as NASH Rx failures are becoming the norm).
    Any of the new IPOs that have great p.o.c Science that are worth a look?


  16. Alex
    Check KYMR S1A
    Ohad liked ARVN. He may like KYMR even more bc of the better targets and partners. Expensive for preclinical but the new technologies typically have a high price tag.


  17. Alex,
    Thanks. I’d already put KYMR on my watch list but agree it’s expensive for a pre-clinical.
    KURA…..has broken out and up finally. Does anyone have a sense of the potential for their pipeline. I know Ohad liked it but felt it had a limited scope. I’m not sure if that opinion has changed.
    Looking for an exit range.
    Thanks All


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